L Theanine---a compound that can soothe the mind and body

2024-12-20
L Theanine
Tea is the second most consumed beverage in the world and is loved for its unique flavor and health benefits. Tea consumption is believed to bring tranquility, reduce tension and alleviate stress, effects that are largely attributed to the abundance of L-theanine in tea leaves.

What is l-theanine

Theanine is a non-proteinogenic amino acid unique to tea, first isolated from green tea in 1950, with sweet and fresh flavor, one of the characteristic amino acids of tea, accounting for about 50%-60% of the total amino acids in tea. The naturally occurring theanines are L-type, while most of the synthetic theanines are a mixture of D-type and L-type; due to the different configuration, the metabolic bioactivity of D-theanine in the body is very low, while the L-type bioactivity is higher.

What does l theanine do

L-theanine is able to cross the blood-brain barrier and directly affect the brain. In the brain, it may target brain chemicals that regulate arousal, anxiety, pleasure and attention .
L-Theanine increases brain serotonin and dopamine levels, which improves memory and learning. It also increases the levels and effectiveness of GABA (the body's primary inhibitory neurotransmitter) and stimulates alpha brainwave activity, which may lead to mental relaxation, concentration and deep REM sleep.
L-Theanine also increases levels of glutathione, the body's most important antioxidant molecule. Given its similarity to the neurotransmitter glutamate, L-theanine may exert its neuroprotective effects by interfering with its function.
What is l-theanine
 

L theanine benefits​

L-theanine has a variety of health effects, including neuroprotection, mental regulation, antioxidant, anti-inflammatory, anticancer, metabolic regulation, cardiovascular protection, liver and kidney protection, immune regulation, genitourinary protection and intestinal protection, etc. Especially in the fight against neurodegenerative diseases and depression, L-theanine shows a very good effect of action.

Studies have proved that L-theanine has an antagonistic effect on the excitement produced by caffeine. When the dosage reaches 1740mg/kg, it can significantly inhibit the nervous system excitation caused by caffeine.

It has been found that after taking  l-theanine for 3-4 months, the learning ability of rats is significantly improved, and they can grasp the essentials in a shorter period of time, and their memory of dangerous environments is also significantly strengthened, so l-theanine can improve the learning ability and memory by regulating the neurotransmitters.
What is l-theanine
Clinical and epidemiological studies have shown that L-theanine can reduce the immunosuppression caused by strenuous exercise, and prevent colds and flu by enhancing immunity. At the same time, a large number of cellular and animal studies have proved that L-theanine can play an immunomodulatory role in inflammation, nerve damage, intestinal tract and tumor by regulating γδT lymphocyte function, glutathione (GSH) synthesis, cytokines and neurotransmitter secretion.    
   

By intraperitoneal injection of L-theanine into mice, researchers found that the systolic blood pressure, diastolic blood pressure and average blood pressure of spontaneous mice were significantly decreased in a dose-response relationship.

Tumor cells have a much more active glutamate metabolism than normal cells, and L-theanine is a derivative of glutamate and a competitor of glutamate, which can inhibit the growth of cancer cells by interfering with the metabolism of glutamate.

L theanine side effects

L-theanine's safety and side-effect free properties are supported by scientific studies worldwide. Its use as a dietary supplement since 1994 has demonstrated its wide acceptance and good tolerability worldwide. GRAS approval from the US FDA further confirms the safety of L-theanine as a food ingredient, and to date there have been no reports of interactions with other drugs, making it a trusted health supplement choice.

L theanine supplement​
 

Clinical trial studies have shown that daily intake of L-theanine 400 mg for 6 weeks was effective in improving sleep rate and sleep quality in boys with ADHD without adverse effects. Daily intake of L-theanine (200 mg) promotes the production of alpha waves in the brain and improves sleep quality in anxiety patients

Anxiety and insomnia are becoming one of the most common “sub-health” problems in the 21st century. Therefore, L-theanine's soothing, calming, and sleep-promoting effects have been widely used to address medical and mental health issues.



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