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Tafluprost ethyl ester

Tafluprost ethyl ester

CAS No. 209860-89-9
Molecular Formula C24H32F2O5
Molecular weight 438.5
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Product Name
Tafluprost ethyl ester
Appearance
10% wt/wt ethanol solution
Specification
 99%
Test Method
HPLC
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder.
Shelf Time
24 months

Tafluprost ethyl ester (also referenced in research as Ethyl Travoprostamide) is a pro-drug of tafluprost, a potent prostaglandin F2α analogue designed to lower intraocular pressure (IOP) in patients with open-angle glaucoma (OAG) and ocular hypertension (OHT). This ethyl ester derivative enhances corneal permeability and metabolic stability, ensuring efficient conversion to the active metabolite, tafluprost acid, within ocular tissues. Its unique formulation addresses limitations of earlier prostaglandin analogs, offering improved efficacy and tolerability.

  1. Tafluprost ethyl ester Superior IOP Reduction
    Tafluprost Ethyl Ester demonstrates 20–30% IOP reduction from baseline, outperforming legacy agents like timolol. Its ethyl ester group facilitates rapid corneal absorption, achieving peak efficacy within 12 hours of topical application.

  2. Tafluprost ethyl ester Dual-Action Mechanism

    • Uveoscleral Outflow Enhancement: Activates prostaglandin FP receptors to relax ciliary muscle and increase aqueous humor drainage.

    • Antioxidant Properties: Emerging studies suggest tafluprost acid may protect retinal ganglion cells from oxidative stress, potentially slowing glaucoma progression.

  3. Tafluprost ethyl ester Enhanced Tolerability
    Unlike older prostaglandin analogs, Tafluprost ethyl ester (Ethyl Travoprostamide) minimizes side effects such as conjunctival hyperemia, eyelash growth, and periocular pigmentation, improving patient adherence.

  4. Tafluprost ethyl ester Stability in Formulation
    The ethyl ester modification ensures compatibility with preservative-free formulations, ideal for patients sensitive to benzalkonium chloride (BAK).