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Neratinib

Neratinib

CAS NO.: 698387-09-6
MF: C30H29ClN6O3
EINECS NO.: 811-237-1
API231
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Product Name
Neratinib
Appearance
Faint yellow powder
Specification
 99%
Test Method
HPLC
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder.
Shelf Time
24 months
  Solubility  Chloroform (Slightly), DMSO (Slightly, Heated, Sonicated), Methanol (Slightly,  Heated)
  Acidity coefficient(pKa)   12.37±0.43(Predicted)

Neratinib is a protein kinase inhibitor used to treat breast cancer that over expresses the HER2 receptor.

Neratinib is used for use as an extended adjuvant treatment in adult patients with early
stage HER2-overexpressed/amplified breast cancer, to follow adjuvant trastuzumab-based therapy 
As an irreversible inhibitor, neratinib may circumvent acquired resistance developed against reversible inhibitors, including gefitinib .