Regarding Metoclopramide (domperidone), you need to know these precautions！
2024-12-13
In daily life, everyone must be familiar with the name of metoclopramide. Its generic name is domperidone, and its main sales dosage form is tablets.
Domperidone is a gastrointestinal prokinetic drug, a peripheral dopamine receptor antagonist, which acts directly on the gastrointestinal wall, can increase gastrointestinal motility and tension, promote gastric emptying, increase antral and duodenal motility, coordinate pyloric contraction, and also enhance esophageal motility and lower esophageal sphincter tension, accelerate gastrointestinal emptying, and thus relieve symptoms caused by poor gastrointestinal motility, such as nausea, vomiting, bloating, abdominal pain, etc. The main indication of metoclopramide is to treat indigestion, bloating, belching, nausea, vomiting, and abdominal pain.
Domperidone has a gastrointestinal motility effect and is mainly used in the following situations:
Mainly used to treat dyspepsia caused by delayed gastric emptying, gastroesophageal reflux, and esophagitis (such as abdominal distension and pain; belching, flatulence; nausea, vomiting, etc.). Gastric burning sensation caused by reflux of gastric contents. Nausea and vomiting caused by other reasons (such as drugs, radiotherapy or chemotherapy, infection).
What do you need to know before taking the medicine?
A.Who should not use it?
1. People who are allergic to this product are prohibited from using it, and those with allergic constitutions should use it with caution.
2. People with diseases that may increase gastric motility and may be dangerous (such as mechanical gastrointestinal obstruction, gastrointestinal bleeding, and perforation) are prohibited from using it.
3. People with prolactinoma, pheochromocytoma, and breast cancer are prohibited from using it.
4. People with moderate to severe liver dysfunction are prohibited from using it.
2. People with diseases that may increase gastric motility and may be dangerous (such as mechanical gastrointestinal obstruction, gastrointestinal bleeding, and perforation) are prohibited from using it.
3. People with prolactinoma, pheochromocytoma, and breast cancer are prohibited from using it.
4. People with moderate to severe liver dysfunction are prohibited from using it.
B. Be careful when using medication for special populations
1. Pregnant women need to consult a physician and weigh the pros and cons of treatment before using this product with caution.
2. Lactating women should stop breastfeeding while taking this product.
3. Children under 12 years old (especially infants), adolescents and adults weighing less than 35 kg, and elderly patients over 60 years old should use it with caution, and adverse reactions should be closely monitored during medication.
4. Patients with renal insufficiency should consult a physician to see if the dosage or medication interval needs to be adjusted.
5. Lactose-intolerant patients should first check the instructions to confirm whether the product contains lactose. Capsules and tablets from some manufacturers contain lactose.
2. Lactating women should stop breastfeeding while taking this product.
3. Children under 12 years old (especially infants), adolescents and adults weighing less than 35 kg, and elderly patients over 60 years old should use it with caution, and adverse reactions should be closely monitored during medication.
4. Patients with renal insufficiency should consult a physician to see if the dosage or medication interval needs to be adjusted.
5. Lactose-intolerant patients should first check the instructions to confirm whether the product contains lactose. Capsules and tablets from some manufacturers contain lactose.
C.Which drugs should not be used together?
1. Do not use with drugs that cause QT interval prolongation (such as clarithromycin, amiodarone);
2. Do not use with strong CYP3A4 enzyme inhibitors (such as fluconazole, voriconazole, ritonavir), which will increase the blood concentration of domperidone in the body;
3. Do not take with antacids or drugs that inhibit gastric acid secretion at the same time, which will reduce the oral bioavailability of domperidone. Domperidone should be taken before meals, and antacids or drugs that inhibit gastric acid secretion should be taken after meals.
4. Do not use with drugs that cause electrolyte disorders (such as furosemide), which will increase the possibility of patients developing torsades de pointes ventricular tachycardia.
2. Do not use with strong CYP3A4 enzyme inhibitors (such as fluconazole, voriconazole, ritonavir), which will increase the blood concentration of domperidone in the body;
3. Do not take with antacids or drugs that inhibit gastric acid secretion at the same time, which will reduce the oral bioavailability of domperidone. Domperidone should be taken before meals, and antacids or drugs that inhibit gastric acid secretion should be taken after meals.
4. Do not use with drugs that cause electrolyte disorders (such as furosemide), which will increase the possibility of patients developing torsades de pointes ventricular tachycardia.
In addition to metoclopramide, what else can be done?
As the Chinese medicine often says: 30% treatment and 70% care for stomach problems, daily diet is the basis for regulating stomach problems.
1. Regular diet: The diet should be warm, soft, light, vegetarian and fresh. Avoid overeating and eat three meals regularly and at regular times.
2. Get rid of the habit of overeating: We need to improve our self-control ability and constantly give ourselves psychological hints. We can use "small meals and frequent meals" to avoid excessive consumption in advance to avoid burdening the stomach.
3. Reasonable exercise after meals: After eating, the stomach has rhythmic peristalsis, so that the food is fully mixed with gastric juice in the stomach, ground into chyme, and gradually emptied. Vigorous activities immediately after a meal directly affect the blood supply of the gastrointestinal tract and cause indigestion. Therefore, it is recommended to do physical activities 1 hour after eating.
4. Keep a good mood: People's emotions are closely related to gastric acid secretion and the digestive function of the stomach. When you are in a low mood, even delicious food will taste like chewing wax. Therefore, keep your mind relaxed and in a good mood when eating.
4. Keep a good mood: People's emotions are closely related to gastric acid secretion and the digestive function of the stomach. When you are in a low mood, even delicious food will taste like chewing wax. Therefore, keep your mind relaxed and in a good mood when eating.
What is the contact information?
Xi'an Rui Zelin Bio Tech Inc. Was Established In 2004 And Has More Than 17 Years Of Experience In Import And Export Of Foreign Trade. It Is a Large-Scale Gold Supplier Integrating Production And Sales. We Also Provide Api,Vitamins,Cosmetic Ingredients Manufacturing Service.
We have a strong professional R&D team, excellent talents and well-equipped laboratories for quality control.
All products are in accordance with international standards, with more than five years of experience in technical inspection personnel, with advanced testing equipment, with their own independent, fully equipped testing laboratory, and strive to provide customers with high quality products and services.
At present, the hot product Domperidone powder raw material is widely used in medicine and other aspects.
Xi'an Rui Zelin Bio Tech Inc. Was Established In 2004 And Has More Than 17 Years Of Experience In Import And Export Of Foreign Trade. It Is a Large-Scale Gold Supplier Integrating Production And Sales. We Also Provide Api,Vitamins,Cosmetic Ingredients Manufacturing Service.
We have a strong professional R&D team, excellent talents and well-equipped laboratories for quality control.
All products are in accordance with international standards, with more than five years of experience in technical inspection personnel, with advanced testing equipment, with their own independent, fully equipped testing laboratory, and strive to provide customers with high quality products and services.
At present, the hot product Domperidone powder raw material is widely used in medicine and other aspects.
Friends who need to buy or are interested can enter our work email through the international website or email info@ruizelinherb.com. We will reply to you as soon as possible; In addition, you can also come to the offline field visit. Our company is located at Room 2413, Building C1, Haijing International, Economic Development Zone, Fengcheng 2nd Road, Xi 'an, Shaanxi Province.
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