NMN, the mechanism of improving hair loss
2025-10-10
"Receding hairline" and "thinning hair on top of the head". Nowadays, hair loss is no longer an exclusive problem for middle-aged and elderly people. More and more young people are worried about their increasingly thinning hair in the mirror. Many studies have confirmed that NMN can improve hair loss.
01
Improving Blood Circulation in the Hair Follicle Microenvironment
Vasodilation Effect
In vascular endothelial cells, increased NAD⁺ activates endothelial nitric oxide synthase (eNOS), prompting it to produce nitric oxide (NO). NO is a potent vasodilator that dilates the blood vessels surrounding the hair follicles.
Good blood circulation is crucial for the health of hair follicles. Hair follicles receive oxygen and nutrients, such as glucose, amino acids, and various vitamins, through the bloodstream. These substances are essential for hair growth. When the blood vessels surrounding the hair follicles dilate and blood flow increases, the hair follicles receive a more adequate supply of nutrients, creating favorable conditions for normal hair growth.
In the hair follicle microenvironment, inflammation can damage vascular endothelial cells and affect blood circulation. NMN modulates intracellular inflammatory signaling pathways, such as inhibiting the activity of nuclear factor-κB (NF-κB), reducing the production of inflammatory factors and thereby alleviating the inflammatory response in the vascular endothelium.
Improving Blood Circulation in the Hair Follicle Microenvironment
Vasodilation Effect
In vascular endothelial cells, increased NAD⁺ activates endothelial nitric oxide synthase (eNOS), prompting it to produce nitric oxide (NO). NO is a potent vasodilator that dilates the blood vessels surrounding the hair follicles.
Good blood circulation is crucial for the health of hair follicles. Hair follicles receive oxygen and nutrients, such as glucose, amino acids, and various vitamins, through the bloodstream. These substances are essential for hair growth. When the blood vessels surrounding the hair follicles dilate and blood flow increases, the hair follicles receive a more adequate supply of nutrients, creating favorable conditions for normal hair growth.
In the hair follicle microenvironment, inflammation can damage vascular endothelial cells and affect blood circulation. NMN modulates intracellular inflammatory signaling pathways, such as inhibiting the activity of nuclear factor-κB (NF-κB), reducing the production of inflammatory factors and thereby alleviating the inflammatory response in the vascular endothelium.
02
Enhancing Hair Follicle Stem Cell Activity
Activating Signaling Pathways Related to Hair Follicle Stem Cell Proliferation
Hair follicle stem cells are a key source of hair regeneration. NMN can activate multiple signaling pathways in hair follicle stem cells, promoting their proliferation. For example, increased NAD⁺ levels can activate the Sirtuins family of proteins (such as SIRT1). SIRT1 plays an important role in cell proliferation, differentiation, and aging.
Enhancing Hair Follicle Stem Cell Activity
Activating Signaling Pathways Related to Hair Follicle Stem Cell Proliferation
Hair follicle stem cells are a key source of hair regeneration. NMN can activate multiple signaling pathways in hair follicle stem cells, promoting their proliferation. For example, increased NAD⁺ levels can activate the Sirtuins family of proteins (such as SIRT1). SIRT1 plays an important role in cell proliferation, differentiation, and aging.
In hair follicle stem cells, SIRT1 regulates cell cycle-related proteins such as p21 and p53. SIRT1 deacetylates these proteins, enabling hair follicle stem cells to smoothly transition from the quiescent phase to the proliferative phase.
When the proliferation capacity of hair follicle stem cells is enhanced, they can provide a larger source of cells for hair growth, facilitating the formation of new hair.
When the proliferation capacity of hair follicle stem cells is enhanced, they can provide a larger source of cells for hair growth, facilitating the formation of new hair.
03
Regulating Hair Follicle Metabolic Balance
Lipid Metabolism Regulating
Lipids secreted by the sebaceous glands of hair follicles also have a significant impact on hair health. NMN can regulate lipid metabolism in hair follicles. It affects enzymes involved in lipid synthesis and secretion in sebaceous gland cells, maintaining a balanced lipid secretion.
For example, when sebaceous glands secrete excessive oil, this can lead to clogged hair follicles, causing seborrheic dermatitis, and ultimately hair loss. NMN can regulate lipid metabolism to prevent excessive sebaceous gland secretion, maintain patency of hair follicles, and create a favorable environment for hair growth.
04
Related Research
Scientists at Harvard Medical School and a team led by Professor Ichiro Kanai of Japan have experimentally demonstrated that NMN may have the potential to promote healthy hair growth and improve hair quality.
Chinese researchers published a study in the journal Molecules showing that NMN has significant anti-inflammatory and antioxidant effects.
In the hair loss model, NMN can reduce the expression of inflammatory factors (such as IL-6 and TNF-α) and reduce the damage of oxidative stress to hair follicles.
A study from Korean scientists found that NMN combined with growth factor cocktail therapy (GFC) can help improve hair loss.
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