Fructus evodiae and Evodiamin
2024-07-12
Evodiae fructus (EF, known in Chinese as Wu Zhu Yu), is the dried, nearly ripe fruit of Evodia rutaecarpa (Juss.) Benth. The plant is a herb used in Traditional Chinese Medicine for gastrointestinal disorders, cardiovascular diseases, headache, amenorrhea, abdominal pain, dysentery, and postpartum hemorrhage . EF has been used for thousands of years in China,
Evodia fruit is used as herbal medicine prepared from the matured fruit of the Evodia rutaecarpa Bentham or Evodia officinalis Dode, of the Rutaceae family. It is used as a stimulant for digestive enzymes, and as a diuretic and analgesic. It is widely used in Japan as a component of Kampo medicine, whereas in Asia it is used as a single herbal medicine. An extract of Evodia fruit in the presence of NADPH was shown to inhibit human liver microsomal erythromycin N-demethylation activity (CYP3A4) (Iwata et al., 2005). Further it was shown that the components of Evodia fruit extract have pre-incubation time dependent inhibitory effects on CYP3A4.
Evodiamine is a naturally occurring indole alkaloid, being the main bioactive component of Evodia rutaecarpa. It has various kinds of pharmacological activities including anti-tumor, protecting the heart, causing weight loss and anti-inflammatory, analgesic and anti-senile dementia.
Evodiamine has stomachic, analgesic, stop dry vomiting and stop belching and other effects; diuretic effect; strong inhibition of Escherichia coli; pig roundworms have significant insecticidal effect; there are contraction of the uterus and the role of elevated blood pressure. It is also effective in the treatment of Alzheimer's disease and stroke.
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