D-Cloprostenol isopropyl ester

D-Cloprostenol isopropyl ester

CAS No. 157283-66-4
MFC25H35ClO6
Molecular weight 466.99
API409
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Product Name
D-Cloprostenol isopropyl ester
Appearance
Colorless oil Liquid 
Specification
 99%
Test Method
HPLC
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder.
Shelf Time
24 months

D-Cloprostenol isopropyl ester Primary Functions‌

‌Prostaglandin FP Receptor Agonism‌
Acts as a potent ‌FP receptor agonist‌ with high affinity (Ki = 28 nM), mimicking the activity of prostaglandin F2α‌.
Stimulates androgen synthesis and spermatogenesis in mice models at 25 μg/kg doses‌.
‌Ocular Effects‌
Induces ‌pupillary constriction‌ and reduces intraocular pressure (IOP) in primates and cats, supporting its potential in glaucoma research‌.
‌Luteolytic Activity‌
Triggers ‌luteolysis‌ (corpus luteum regression) by reducing progesterone levels, aiding in reproductive cycle regulation‌

‌Pharmaceutical Research‌
D-Cloprostenol isopropyl ester Serves as a critical ‌intermediate‌ in synthesizing (+)-Cloprostenol and other prostaglandin-based therapeutics‌.
Utilized in preclinical studies targeting FP receptor-mediated pathways, such as fertility management and ocular hypertension‌14.
 
‌Veterinary Medicine‌
D-Cloprostenol isopropyl ester Applied in livestock breeding to synchronize estrus cycles and enhance reproductive efficiency‌.
 
‌Industrial Synthesis‌
D-Cloprostenol isopropyl ester Used in large-scale production of prostaglandin analogs for therapeutic formulations‌